Antihistamine therapy involves taking H1 (diphenhydramine, cetirizine, loratadine) and H2 (ranitidine, famotidine) receptor antagonists. Early observational studies and anecdotal reports show promising results, but the exact mechamism of action is unknown.
There's one study on the use of antihistamine therapy for long COVID, but further research is very likely to change our confidence in this treatment's effects.
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